Evidence map›Paper›PMID 41878579›Full record

SynthesisFrontiers in nutrition2026

Sarcopenia as a risk factor for nonalcoholic fatty liver disease and liver fibrosis: an updated systematic review and meta-analysis.

Xinrong Zuo, Doudou Chen, Yi Kang, Xinyi Hu, Yarong Zhang, Kuo Tang, Junhua Shi, Tao Li, Wangning Shangguan

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xinrong Zuo *Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Doudou Chen *Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Yi KangDepartment of Anesthesiology, Laboratory of Mitochondrial Metabolism and Perioperative Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Xinyi HuMetabolomics and Proteomics Technology Platform, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Yarong ZhangState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Kuo TangDepartment of Anesthesiology, Laboratory of Mitochondrial Metabolism and Perioperative Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Junhua ShiDepartment of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Tao LiDepartment of Anesthesiology, Laboratory of Mitochondrial Metabolism and Perioperative Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Wangning ShangguanDepartment of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Sarcopenia, an age-related skeletal muscle disorder with metabolic dysregulation, has been linked to various chronic diseases. Emerging evidence suggests a bidirectional relationship with nonalcoholic fatty liver disease (NAFLD), though the epidemiological and mechanistic links remain unclear. This study aimed to assess the prevalence of sarcopenia in NAFLD populations and its association with NAFLD and liver fibrosis. Methods: PubMed, EMBASE, MEDLINE, Cochrane Library, and Web of Science databases were searched for eligible studies published until August 6, 2025. Two validated tools assessed the study quality and risk of bias. Statistical analyses were conducted using STATA 17.0. This study has been registered on PROSPERO (CRD420251021280). Results: From 4,938 screened records, 41 studies ( Conclusion: This study confirms a high prevalence of sarcopenia in NAFLD populations and a significant association with NAFLD and liver fibrosis, supporting its role as a modifiable risk factor. However, heterogeneity due to diagnostic variability remains a limitation. Standardized criteria and longitudinal studies are needed to establish causality. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/, PROSPERO: CRD420251021280.

Indexed as

hepatic fibrosismetabolic dysfunction-associated steatotic liver diseasenonalcoholic fatty liver diseaseprevalencesarcopenia

Identifiers

PMID41878579
PMCPMC13006315

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.