ArticleCurrent medicinal chemistry2026
Biochemical Analysis of Inflammatory Markers and Oxidative Stress Biomarkers in Oral Squamous Cell Carcinoma: A Comprehensive Case-Control Study.
Article in Current medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Advances in Medicinal Chemistry: From Cancer to Chronic Diseases (Part I).Current medicinal chemistry · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOral squamous cell carcinoma (OSCC) represents a significant global health burden with complex pathophysiology involving chronic inflammation and oxidative stress. Systemic inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), have emerged as potential prognostic indicators, while oxidative stress biomarkers such as 8-hydroxy-2'-deoxyguanosine (8-OHdG) reflect DNA damage associated with carcinogenesis.
objectiveThis study aimed to evaluate the diagnostic potential of NLR, PLR, and oxidative stress biomarkers in OSCC patients, investigating the relationship between systemic inflammation, oxidative DNA damage, and antioxidant status in the context of oral carcinogenesis.
methodsA case-control study was conducted involving 138 participants (82 OSCC patients and 56 healthy controls) aged 28-48 years. Comprehensive hematological analysis was performed using automated analyzers, while serum concentrations of interleukin-6 (IL-6), C-reactive protein (CRP), 8-OHdG, and vitamin C were quantified using enzyme- linked immunosorbent assay (ELISA) techniques. Statistical analysis included independent t-tests and Pearson correlation analysis.
resultsOSCC patients demonstrated significantly elevated levels of white blood cells (13.01±4.31 vs. 4.54±7.32 ×10 DISCUSSION: The significant elevations in inflammatory and oxidative stress biomarkers, coupled with their strong correlations with tumor stage, suggest these markers reflect the complex interplay between chronic inflammation and oxidative damage in OSCC pathogenesis. The exceptional diagnostic accuracy of the combined biomarker panel (NLR + IL-6 + 8-OHdG; AUC = 0.995) demonstrates the potential clinical utility of integrating multiple pathophysiological pathways for improved OSCC detection and risk stratification.
conclusionElevated NLR and PLR values, combined with increased oxidative stress markers and diminished antioxidant capacity, reflect the complex interplay between chronic inflammation and oxidative damage in OSCC pathogenesis. These biomarkers may serve as valuable adjunctive tools for early detection and prognostic assessment in oral cancer management.
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