ArticleJACC. Case reports2026
Extreme Malignant Hypertension Resulting in Dialysis-Dependent Hypertensive Nephrosclerosis.
Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
backgroundMalignant hypertension is a life-threatening condition characterized by severe blood pressure elevation with acute target-organ damage, requiring prompt but controlled management. CASE SUMMARY: A 56-year-old woman presented with headache was found to have extreme hypertension. Despite repeated automated and manual measurements, blood pressure remained markedly elevated, prompting arterial line placement, which confirmed a blood pressure of 327/149 mm Hg. Secondary causes of hypertension were excluded. The patient was treated with intravenous nicardipine, followed by transition to maximally titrated oral antihypertensives. DISCUSSION: Although hypertensive emergencies are well described, arterial line-confirmed blood pressures exceeding 320 mm Hg are exceedingly rare. This case highlights the importance of accurate blood pressure measurement, guideline-directed blood pressure reduction, and the devastating renal consequences of untreated hypertension. TAKE-HOME MESSAGES: Accurate confirmation of extreme blood pressure values and controlled, guideline-directed reduction are essential to prevent ischemic complications in malignant hypertension. Successful management of malignant hypertension requires coordinated multidisciplinary care, continuous monitoring, and adherence to evidence-based blood pressure reduction strategies.
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