Evidence map›Paper›PMID 41879847›Full record

ReviewCurrent microbiology2026

The Gut-Brain-Cardiac Axis: How Microbiota Influence Cognitive and Cardiovascular Health.

Vikram Kumar, Bharmjeet Singh, Archana Ayyagari, Deepti N Chaudhari, Jayesh J Ahire

Abstract readReview
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In one paragraph

Review in Current microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vikram KumarDepartment of Microbiology, Swami Shraddhanand College, University of Delhi, New Delhi, 110036, India.
Bharmjeet SinghInternational Centre for Genetic Engineering and Biotechnology, New Delhi, 110067, India.
Archana AyyagariDepartment of Microbiology, Swami Shraddhanand College, University of Delhi, New Delhi, 110036, India.
Deepti N ChaudhariMIT School of Food Technology, MIT-ADT University, Pune, 412201, India.
Jayesh J AhireDr. Reddy's Laboratories Limited, Hyderabad, 500016, India. jjahire@gmail.com.ORCID http://orcid.org/0000-0002-1142-8630

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut-brain-heart axis represents a dynamic interplay between the gut microbiota, cognitive function, and cardiovascular health, with profound implications for understanding and managing chronic diseases. In dysbiosis, a disruption in microbial balance contributes to neuro-inflammation, mood disorders, neurodegenerative diseases, and cardiovascular conditions such as atherosclerosis and hypertension. To date, researchers explored different mechanism through which gut microbial communities influence the activities of brain and heart. In order to understand these mechanisms summative, in this review, we focused on key communication pathways between microbiota-gut-brain-heart, such as vagus nerve, gut-derived metabolites, and systemic inflammation. Furthermore, the review discusses the bidirectional nature of these relationships, where cardiovascular and cognitive health mutually influence one another. Therapeutic interventions, including probiotics, dietary modifications, biotechnological approach and lifestyle changes are evaluated for their potential to modulate the gut-brain-heart axis and improve health outcomes. Despite significant advances, challenges remain in understanding the complex interactions within this axis. Future research directions emphasize personalized medicine approaches and the potential of microbiome-targeted therapies to revolutionize the prevention and treatment of cognitive and cardiovascular disorders.

Indexed as

BrainCardiovascular DiseasesCognitionGastrointestinal MicrobiomeHeartAnimalsDysbiosisHumansProbiotics

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.