ReviewCurrent HIV/AIDS reports2026
To Switch or not to Switch: are there any Antiretroviral Strategies to Attenuate Weight Gain in People with HIV?
Review in Current HIV/AIDS reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Prevalence and associated factors of malnutrition among adults living with HIV on ART: a pilot study.Metabolism open · 2026Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewWeight gain and development of obesity has been well-described with contemporary antiretroviral therapy (ART), and management has proven difficult. It remains unclear whether weight gain can be mitigated or reversed by switching ARV classes. We aim to summarize recent literature on ART switch to attenuate weight gain. RECENT
findingsRecent studies have recognized integrase strand transfer inhibitors (INSTI) and tenofovir alafenamide (TAF) as significant independent contributors to weight gain. The mechanisms for weight gain may stem from adipose tissue hypertrophy and fibrosis. The reversibility of the weight gain appears to be limited, with trials evaluating switching to more “weight-neutral” ART not proving effective. Discontinuing INSTI- and/or TAF-based regimens has not led to significant changes in weight, suggesting that alternative strategies may be required to modify weight trajectories in individuals who experience excessive weight gain after initiating INSTI-based ART.
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Registered trials
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