Evidence map›Paper›PMID 41880422›Full record

ReviewPLoS computational biology2026

Physical models of embryonic epithelial healing.

Rafael Franco Almada, Nuno André Miguel Araújo, Pedro Patrício

Abstract readReview
In one paragraph

Review in PLoS computational biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Rafael Franco AlmadaCentro de Física Teórica e Computacional, Faculdade de Ciências da Universidade de Lisboa, Lisboa, Portugal.ORCID https://orcid.org/0009-0000-9586-6082
Nuno André Miguel AraújoCentro de Física Teórica e Computacional, Faculdade de Ciências da Universidade de Lisboa, Lisboa, Portugal.ORCID https://orcid.org/0000-0002-1677-6060
Pedro PatrícioCentro de Física Teórica e Computacional, Faculdade de Ciências da Universidade de Lisboa, Lisboa, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Embryonic healing in epithelial tissues is distinct from adult wound healing, as it lacks inflammatory responses or immune cell recruitments, making it ideal to test models of wound healing driven primarily by epithelial dynamics. Many models have been developed to describe this process, ranging from simple mechanistic models to more elaborate multiscale simulations. We review different classes of physical models, from discrete to continuum models, and how they address key questions about the mechanics, signaling, and coordination of cells during wound closure. We highlight tensions between model complexity and interpretability and discuss recent efforts to bridge gaps across scales. Finally, we identify directions for hybrid modeling and model-experiment integration that could push forward our understanding of epithelial repair in development and disease.

Indexed as

Models, BiologicalWound HealingAnimalsComputer SimulationEpithelial CellsEpitheliumHumansSignal Transduction

Identifiers

PMID41880422
PMCPMC13016479

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.