In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Briar BellDepartment of Biochemistry and Molecular Biology, Center for Membrane Biology, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0001-9797-6402 Angela M Jaramillo-GranadaDepartment of Biochemistry and Molecular Biology, Center for Membrane Biology, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0001-6122-2350 Luis O RomeroDepartment of Biochemistry and Molecular Biology, Center for Membrane Biology, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0001-9855-7592 Irene A GutierrezDepartment of Molecular Biosciences, University of South Florida, Tampa, FL, USA.
Venkata K P S MallampalliStructural Biology Imaging Center at the University of Texas Health Science Center at Houston, Houston, TX, USA.
Guizhen FanDepartment of Biochemistry and Molecular Biology, Center for Membrane Biology, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0002-6741-6989 Matthew L BakerDepartment of Biochemistry and Molecular Biology, Center for Membrane Biology, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0001-9039-8523 Irina I SeryshevaDepartment of Biochemistry and Molecular Biology, Center for Membrane Biology, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0001-6266-3422 Valeria VásquezDepartment of Biochemistry and Molecular Biology, Center for Membrane Biology, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0001-8494-1534 Julio F Cordero-MoralesDepartment of Biochemistry and Molecular Biology, Center for Membrane Biology, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0002-6505-5403 Funding
ACQUISITION OF HIGH-THROUGHPUT 200 kV CRYO-TEMS10OD032204 · OD · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SERYSHEVA, IRINA I · 2022 to 2022
$2.0MTraining Core: Houston Area Incubator for Kidney, Urologic and Hematologic Research Training (HAIKUH)TL1DK147564 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI MARGARET A. GOODELL · 2025 to 2026
$1.8MMechanisms of inositol trisphosphate receptor-mediated calcium signalingR35GM153178 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Irina I Serysheva · 2024 to 2026
$1.7MMechanosensitive Ion Channels Modulation by Membrane CompositionR35GM153208 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Valeria Vasquez · 2024 to 2026
$1.2MAmerican Heart Association-American Stroke Association 23CDA1048883NIDDK NIH HHS TL1 DK147564NIGMS NIH HHS R35 GM153178NIGMS NIH HHS R35 GM153208NIH HHS S10 OD032204
6 · The paper itselfAbstract
Cerebellar ataxias are characterized by impaired motor coordination resulting from neuronal dysfunction within the cerebellum. The mechanisms underlying this pathology and its cerebellar-specific neurodegeneration remain unknown. We uncover how a gain-of-function canonical transient receptor potential member 3 (TRPC3) mutation, coupled with a cerebellum-specific isoform, stabilizes the channel's open state, resists the leading inhibitor Pyr3, and drives calcium-dependent cell death. Restoring calcium homeostasis by expressing a Purkinje cell calcium pump improves cell viability. Transgenic expression of the TRPC3 hypermorphic variant in
Indexed as
Cerebellar AtaxiaMutationTRPC Cation ChannelsAnimalsAnimals, Genetically ModifiedCaenorhabditis elegansCalciumCerebellumHumansPurkinje CellsCalciumTRPC3 cation channelTRPC Cation Channels
Identifiers
PMID41880503
PMCPMC13015894
What Socratic holds
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