ArticleSleep medicine2026
Polysomnography demonstrates worse sleep in children and adolescents with disorders of gut-brain interaction (DGBI) compared to healthy children: A case-control study.
Article in Sleep medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Abstract
backgroundChildren with disorders of gut-brain interaction (DGBI) often report poor sleep. However, the presence of sleep disorders and polysomnography (PSG) characteristics have not been previously described. Thus, we aimed to compare PSG changes in children with DGBI compared to healthy controls and describe sleep disorders in DGBI patients.
methodsWe conducted retrospective review of patients ages 7-19 y who met Rome 4 criteria for DGBI without organic GI, systemic conditions and underwent PSG at Cincinnati Children's Sleep Center within one year of the GI clinic visit. We collected demographics, GI and sleep symptoms and diagnosis, and PSG metrics. We compared PSG metrics of children with DGBI to a control group of ages 4-18 years from CCHMC sleep research repository. Linear regression analyses, adjusting covariates, were conducted to examine differences between groups.
resultsOf 102 children with DGBI, mean age: 13.9y ± 3.3, 66% were females, 88% were Caucasian, 30% had irritable bowel syndrome, 29% had functional abdominal pain, and 21% had functional dyspepsia. Of 203 controls, mean age: 10.7y ± 2.6, 57% were females, and 64% were Caucasian. DGBI patients had significantly lower sleep efficiency after onset, less NREM3 and REM sleep, and shorter REM latency and REM cycles than healthy controls (all p's ≤ 0.05). Patients also had significantly higher apnea, arousal index, arousal episodes, and periodic limb movements (all p's < 0.0001).
conclusionChildren with DGBI demonstrate significant PSG-derived disruptions in sleep architecture, including less NREM3, elevated apnea, arousal episodes, and periodic limb movements than healthy controls.
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