ArticleScientific reports2026
Access to β-acetoxyselenides, perhydroindolones and anticancer piperidinones via blue LED-driven selenylation of unsaturated carboxamides.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blue LED-initiated selenylation of unsaturated acid amides with diorganyl diselenides in acetic and formic acids was shown to proceed either through a three-component conjugate addition to the double C=C bond, or via selenocyclization, depending on the N-substituent and solvent. The latter occurs as O-cyclization via the exo-trig mode to give iminolactones/lactones or as N-cyclization via the 5-exo-trig and 6-endo-trig modes to give selenyl-functionalized perhydroindolones and piperidinones, respectively. Among the synthesized compounds, the piperidinone derivative 12ea exhibited the greatest antiproliferative potency in human cervical carcinoma (HeLa) and human colorectal carcinoma (HCT-116) cells, with half-maximal inhibitory concentration (IC50) values in the micromolar range. Mechanistic studies revealed induction of apoptosis, confirmed by caspase-3/7 activation, Annexin V/propidium iodide staining, and nuclear abnormalities with γH2AX foci, consistent with DNA damage and mitotic stress. In three-dimensional spheroid models, 12ea effectively suppressed tumor-like growth and promoted apoptotic cell death. These findings identify 12ea as a promising and selective lead compound for further development in anticancer drug discovery.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.