ArticleNPJ cardiovascular health2026
Berberine signature and cardiometabolic diseases using randomized controlled trial, cohort study and Mendelian randomization.
Article in NPJ cardiovascular health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03770325 (Effect of Berberine on Cardiovascular Disease Risk Factors), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Berberine on Cardiovascular Disease Risk Factors: a Mechanistic Randomized Controlled Trial
Who cites it
1 citing paper in PubMed.
- Metabolic and Anti-Inflammatory Effects of Berberine-Rationale for Its Therapeutic Potential in Polycystic Ovary Syndrome.International journal of molecular sciences · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Berberine lowers both lipids and glucose, yet its role on cardiometabolic disease risk remain unclear. Based on a randomized controlled trial of berberine (registered in ClinicalTrials.gov on Dec 2018, NCT03770325), leveraging proteomics and sex hormones data, we built a signature reflecting response to berberine using elastic net regression. We then assessed its associations with ischemic heart disease (IHD) and diabetes in UK Biobank using logistic regression and for causal relationship, using bi-directional Mendelian randomization (MR), and estimates of each protein/hormone. The signature was related to lower IHD and diabetes risks (OR for IHD 0.85, 95% CI 0.79-0.91; diabetes 0.88, 0.80-0.96 using MR). SHBG and PRSS2 might explain the beneficial association with IHD; testosterone, SHBG, CCL5, CNDP1, F11, LCN2, and THBS4 might explain the association with diabetes, which provides insights for drug development. Our study suggests beneficial associations of berberine with IHD and diabetes, which requires confirmation in large clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.