Evidence map›Paper›PMID 41882175›Full record

ArticleNature biomedical engineering2026

Human microphysiological systems of aging recreate the in vivo process expediting evaluation of anti-geronic strategies.

Lin Qi, Yuchen He, Alexandra Sviercovich, Xiaoyue Mei, Erzhen Chen, Yihan Xia, Michael J Conboy, Irina M Conboy, Andreas Stahl

Abstract read
PubMed Publisher
In one paragraph

Article in Nature biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lin QiDepartment of Nutritional Science and Toxicology, College of Natural Resources, University of California Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0000-0001-7398-327X
Yuchen HeDepartment of Nutritional Science and Toxicology, College of Natural Resources, University of California Berkeley, Berkeley, CA, USA.
Alexandra SviercovichDepartment of Bioengineering and QB3 Institute, University of California Berkeley, Berkeley, CA, USA.
Xiaoyue MeiDepartment of Bioengineering and QB3 Institute, University of California Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0000-0003-0660-5767
Erzhen ChenDepartment of Nutritional Science and Toxicology, College of Natural Resources, University of California Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0009-0003-5829-1509
Yihan XiaDepartment of Nutritional Science and Toxicology, College of Natural Resources, University of California Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0009-0008-1051-4423
Michael J ConboyDepartment of Bioengineering and QB3 Institute, University of California Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0000-0002-6434-4772
Irina M ConboyGeneration Lab, San Francisco, CA, USA. irina@generationlab.co.ORCID http://orcid.org/0000-0002-4276-0644
Andreas StahlDepartment of Nutritional Science and Toxicology, College of Natural Resources, University of California Berkeley, Berkeley, CA, USA. astahl@berkeley.edu.ORCID http://orcid.org/0000-0002-9096-3024

Funding

Identifying signatures of brain aging through heterochronic blood exchangeR01AG071787 · UNIVERSITY OF CALIFORNIA SANTA CRUZ · 2025 to 2025
$444k
NIDDK NIH HHS UG3 DK120004NIDDK NIH HHS UH3 DK120004United States Department of Defense | United States Army | Army Medical Command | Congressionally Directed Medical Research Programs (CDMRP) TX230133U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) 1UG3DK120004U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01AG071787
6 · The paper itself

Abstract

The search for biological mechanisms of human aging is stalled by a lack of suitable models, and it remains unknown whether and to what degree rejuvenation reported in rodents translates to people. Here we report a human induced pluripotent stem cell-derived microphysiological system modelling the white adipose tissue-liver axis in the presence of heterochronic human serum to study aging and rejuvenation in humans. We reveal changes in functional and molecular hallmarks of aging and rejuvenation. We also investigate unknown biomarkers and mechanisms of plasticity in human tissue aging and potential rejuvenation strategies. The microphysiological chip recapitulates, in 4 days, aging-associated hallmarks that occur after decades of aging in people, including gerontic shifts in gene expression and oxidative DNA damage. We uncover unknown signalling networks in human aging, knock-on effects of aging in fat on liver, sexual polymorphisms of aging and tissue memory of age, and develop a custom machine learning model for biological age. Combining heterochronic human serum with the microphysiological system allows for rapidly establishing human tissue aging, discovering clinically relevant mechanisms and biomarkers, and testing of anti-geronic approaches.

Identifiers

PMID41882175

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.