ArticleFrontiers in pharmacology2026
Risk factors for drug-related gastrointestinal ulcer:a retrospective pharmacovigilance study.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Despite the fact that many medications have been linked to gastrointestinal ulcers, the extent to which most of these drugs contribute to such ulcers is not well understood. This study investigates the risk factors linked to gastrointestinal ulcers caused by drugs by analyzing large datasets obtained from the FDA Adverse Event Reporting System (FAERS). Methods: The data from the first quarter of 2015 to the third quarter of 2025 were analyzed using the report odds ratio (ROR), combined with single-factor, LASSO, and multivariate regression analysis methods, to thoroughly investigate the risk factors associated with drug-related gastrointestinal ulcers. Results: A total of 983 medications linked to adverse events concerning gastrointestinal ulcers were identified in this study, which included 21,191 patients. The medications most frequently linked to gastrointestinal ulcers include nonsteroidal anti-inflammatory drugs, anticoagulants, antiplatelet agents, and immunosuppressants. In the multifactorial logistic regression analysis, Sevelamer and acetylsalicylic acid emerged as the two medications most strongly associated with the highest incidence of gastrointestinal ulcer cases. Conclusion: Nonsteroidal anti-inflammatory drugs, Sevelamer, immunosuppressants, and other medications have shown a significant positive association with gastrointestinal ulcers. These findings provide hypothetical clues for pharmacovigilance; however, establishing a causal relationship requires further validation through prospective studies in populations.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.