Evidence map›Paper›PMID 41884003›Full record

ArticleiScience2026

Retinoic acid regulates fetoplacental vascularization via notch signaling and a SEMA3E/F-PLEXIND1 axis.

Aleksandra Cwiek, Umadevi Paila, Zaneta Markowska, Nafiisha Genet, Madeline Jackson, Gael Genet, Shelby R Cain, Jordon W Aragon, Elizabeth A Nelson, Ricardo Moraes Borges and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Aleksandra CwiekDepartment of Cell Biology and Developmental Genomics Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Umadevi PailaDepartment of Cell Biology and Developmental Genomics Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Zaneta MarkowskaDepartment of Cell Biology and Developmental Genomics Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Nafiisha GenetDepartment of Cell Biology and Developmental Genomics Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Madeline JacksonDepartment of Cell Biology and Developmental Genomics Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Gael GenetDepartment of Cell Biology and Developmental Genomics Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Shelby R CainDepartment of Cell Biology and Developmental Genomics Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Jordon W AragonDepartment of Cell Biology and Developmental Genomics Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Elizabeth A NelsonDepartment of Cell Biology and Developmental Genomics Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Ricardo Moraes BorgesDepartment of Cell Biology and Developmental Genomics Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Ann E SutherlandDepartment of Cell Biology and Developmental Genomics Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Karen K HirschiDepartment of Cell Biology and Developmental Genomics Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

Funding

Mechanisms of mechanotransduction during neural tube morphogenesisR01HD107872 · NICHD · UNIVERSITY OF VIRGINIA · PI Xiaowei Lu, Ann E Sutherland · 2022 to 2026
$2.7M
High-speed and high-resolution Zeiss880 multiphoton microscopy systemS10OD025156 · OD · UNIVERSITY OF VIRGINIA · PI PERIASAMY, AMMASI · 2019 to 2019
$600k
Tunable White Light Laser Confocal/Spectral Imaging MicroscopyS10RR025616 · NCRR · UNIVERSITY OF VIRGINIA · PI PERIASAMY, AMMASI · 2009 to 2009
$500k
NCRR NIH HHS S10 RR025616NICHD NIH HHS R01 HD107872NIH HHS S10 OD025156
6 · The paper itself

Abstract

The placenta is vital for fetal development, and altered placental vascularization, the most common placental pathology, underlies prevalent disorders, including fetal growth restriction, prematurity, and pregnancy complications. Impaired placental vascularization is associated with Vitamin A deficiency, but the mechanisms are undefined. To investigate this, we used retinoic acid (RA)-deficient Raldh2

Indexed as

cell biologydevelopmental biologymolecular biology

Identifiers

PMID41884003
PMCPMC13010106

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.