ArticleInternational journal of biochemistry and molecular biology2026
Gene polymorphisms and occurrence of type 2 diabetes in a Gabonese population.
Article in International journal of biochemistry and molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundType 2 diabetes (T2DM) is a metabolic disease characterized by chronic hyperglycemia. We investigated the relationship between the polymorphisms
methodThis case-control study was conducted at the Endocrinology Department of the University Hospital of Libreville. We enrolled 97 patients with T2DM and, from the general population, 87 control subjects who met the inclusion criteria. Genomic DNA was extracted with the Qiagen kit, and polymorphisms were analyzed using the RFLP method.
resultsFor KCNJ11, the wild type (EE) genotype frequency was 62.2% in controls versus 42.6% in cases, whereas the mutant type (KK) genotype frequency was 28.7% in cases versus 21.1% in controls (P=0.0243). For TCF7L2, the wild type (CC) genotype was found in 51.7% of controls and 37.1% of cases, and the mutant type (TT) genotype was found in 22.7% of cases versus 9.2% of controls (P=0.0253). For SLC30A8, the wild type (CC) genotype occurred in 26.0% of cases and 24.6% of controls (P=0.9326). After adjustment for age and body mass index, the recessive transmission models of
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