ArticleWorld journal of gastrointestinal pathophysiology2026
Hypoalbuminemia as a predictor of mortality in patients with acute cholangitis: A systematic review and meta-analysis.
Article in World journal of gastrointestinal pathophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAcute cholangitis is a potentially life-threatening infection of the biliary tract and its mortality rate is between 10%-30%. Early risk stratification is essential for the best possible outcome. Serum albumin, an index of the inflammatory and nutritional state, has been associated with adverse outcome in various acute conditions.
aimTo assess the value of hypoalbuminemia as a predictor of mortality in acute cholangitis.
methodsA systematic search of PubMed, Web of Science, Semantic Scholar, Cochrane Library, and Google Scholar was performed up to May 2025. Eligible studies included adults diagnosed with acute cholangitis and reported mortality outcomes stratified by serum albumin levels. Data extraction was conducted independently by two reviewers, and study quality was assessed using the Newcastle-Ottawa Scale. Pooled odds ratios (OR) with 95%CI were calculated using a random-effects model. Heterogeneity was assessed with the
resultsEight retrospectively assembled cohort studies enrolling a total of 2215 of patients with acute cholangitis were incorporated in this meta-analysis. Mean age of the patient was greater than 65 years. Among them, 52.2% were males. Out 2215 patients, 242 (10.9%) died. Hypoalbuminemia was highly associated with increased mortality. Dichotomous outcome analysis demonstrated strong evidence of association between hypoalbuminemia and mortality (OR = 8.02, 95%CI: 3.41-18.83;
conclusionHypoalbuminemia on hospital admission is a strong and independent predictor of death in patients with acute cholangitis. Admission serum albumin measurement provides a simple, cost-effective, and universally available method of early risk stratification. Prospective studies in the future need to examine whether correction of hypoalbuminemia improves clinical outcomes.
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