ReviewSynthetic and systems biotechnology2026
Advances in vehicles for in situ delivery: From classical vectors to biologically inspired structures.
Review in Synthetic and systems biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Biomimetic Coacervate Coatings: From Phase Separation Fundamentals to Advanced Biomedical Applications.Biomimetics (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The emerging fields of synthetic biology and gene therapy rely on delivery systems to introduce the nucleic acids and proteins into recipient cells. Hence, the development of delivery tools with high specificity, strong manufacturability, and low immunogenicity can advance these fields. In this review, we summarize recent advances in the development of delivery systems for proteins and nucleic acids. First, we outline viral vector-based delivery tools, including lentivirus, adenovirus, and adeno-associated virus-based delivery technologies, discussing their advantages and limitations. Next, we summarize the advantages and disadvantages of non-viral vector-based delivery tools, including delivery strategies based on lipid nanoparticles, polyethyleneimine, exosomes, cell-penetrating peptides, virus-like particles, gold nanoparticles, and mesoporous silica nanoparticles. Lastly, we examine the specific principles and functional potential of novel delivery systems, including the Arc, PNMA2, SEND, PVC, and Coacervate systems. Overall, this review provides a systematic assessment of the mechanisms of action, current application progress, and future prospects for viral vectors, non-viral vectors, and novel delivery tools. Moreover, this review will serve as a reference for technological development and theoretical research in the fields of synthetic biology and gene therapy.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.