ReviewInternational journal of nanomedicine2026
The Landscape of Ferritin Nanocages for Neurodegenerative Diseases Treatment.
Review in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Molecular Mechanisms and Biomedical Applications of Ferritin Nanocages: A Comprehensive Review of Self-Assembly, Engineering, and Multifunctional Delivery Platforms.International journal of nanomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The blood-brain barrier (BBB) is a sophisticated structure composed of brain capillary endothelial cells, basement membrane, and neuroglial membrane, which strictly regulates substance exchange between the blood and brain tissue. While maintaining the homeostasis of the central nervous system, it blocks the entry of over 98% of small-molecule drugs and nearly all macromolecular drugs into the brain parenchyma, posing a significant challenge for the treatment of neurodegenerative diseases (NDs). Owing to their unique hollow architecture, favorable biocompatibility, reversible self-assembly properties, intrinsic targeting capability, and surface modifiability, natural ferritin nanocages have garnered substantial attention in the fields of biomedicine and nanotechnology. This review outlines the pathological mechanisms of NDs, the structure and function of the BBB, as well as its transport mechanisms. It highlights the advantages of ferritin nanocages in crossing the BBB-attributed to their natural nanostructure, brain-targeting potential, and capacity for functionalized surface modification-along with their drug loading capacity, antioxidant activity, and favorable biosafety profile. Recent advances in the application of natural ferritin nanocages for the diagnosis and therapy of NDs are also summarized. However, it is important to note that the evidence supporting their application in NDs remains more limited compared to their extensive research in cancer therapeutics. Finally, current challenges and future prospects of ferritin-based nanoplatforms are discussed, providing valuable insights for developing ferritin nanocage-based strategies in the diagnosis and treatment of NDs.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.