ArticleInternational journal of nanomedicine2026
Exploring the Potential Role of Manganese-Based Zeolitic Imidazolate Framework Nanoparticles in Cancer Therapy:
Article in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Chemodynamic therapy (CDT) has emerged as a promising cancer treatment strategy leveraging tumor microenvironment conditions to generate reactive oxygen species (ROS) through Fenton-type reactions. This study reports the synthesis, in-depth characterization, and biological evaluation of novel manganese-based zeolitic imidazolate framework (ZIF) nanoparticles, ie, Mn-rods, as a carrier-free potential CDT platform with exceptionally high manganese loading. Methods: Mn-rods were synthesized through coordination of Mn Results: The synthesized Mn-rods exhibited a rod-shaped morphology (226 ± 93 nm length x 26.5 ± 9.5 nm width) with an exceptional Mn Conclusion: These findings establish Mn-rods as potent CDT agents whose efficacy is dictated by tumor cell oxidative vulnerability. Understanding such cell-specific responses is critical for optimizing nanoparticle design and tailoring therapeutic strategies in heterogeneous tumor environments. Future studies should extend these investigations across diverse cancer models to refine their translational potential.
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