ArticleFrontiers in behavioral neuroscience2026
Sex differences in taste neophobia and conditioned aversion across fluid administration methods.
Article in Frontiers in behavioral neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Rodent studies of the taste system commonly employ two methods of taste administration (MOA): active licking from spouts or intra-oral cannula (IOC) deliveries. While bottle drinking preserves natural consumption behavior, IOC administration, where animals receive liquids passively into their oral cavity, provides precise temporal control of stimulus delivery but limits the reliability of measuring voluntary intake and hedonic response. To overcome these limitations, a third method, nose-poke for IOC delivery (NP-IOC), was introduced. In NP-IOC, each taste is delivered through the IOC following an active nose poke, thus combining voluntary decision-making with temporal precision. Whether NP-IOC preserves natural taste-guided behavior, however, remains unknown. Here, we examined how NP-IOC affects taste neophobia (the reluctance to consume novel tastes) and conditioned taste aversion (CTA, avoidance of a taste paired with malaise). Rats received water either
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