ArticleClinical, cosmetic and investigational dermatology2026
Beer Intake is Positively, While Cheese and Dried Fruit Intake Are Negatively Genetically Correlated with Psoriasis: A GWAS Summary-Statistics Study Using condFDR/conjFDR.
Article in Clinical, cosmetic and investigational dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Previous epidemiological investigations have reported associations between beer, cheese, and dried fruit intake and the incidence of psoriasis (PS). Nevertheless, the extent of shared genetic architecture underlying these associations remains insufficiently characterized. Therefore, it is essential to examine their molecular relationships from a genomics perspective. Methods: A stratified, stepwise analytical framework was applied, utilizing genome-wide association study data for PS and three dietary intake patterns (beer, cheese, and dried fruit intake). In the initial phase, linkage disequilibrium score regression, genetic covariance analysis, and high-definition likelihood approaches were employed to quantify genome-wide genetic correlations. Subsequently, local genetic overlap analyses were conducted to delineate chromosomal regions harboring relevant associations. Finally, the conditional/conjunctional false discovery rate (condFDR/conjFDR) methodology was implemented to identify potential shared genetic loci (genetic overlap) across the phenotypes. Results: The analysis revealed consistent genome-wide genetic correlations between psoriasis (PS) and the three dietary intake traits across LDSC, GNOVA, and HDL. PS showed a significant positive genetic correlation with beer intake (Rg = 0.1082 [LDSC], 0.0796 [GNOVA], and 0.144 [HDL]), whereas negative genetic correlations were observed for cheese intake (Rg = -0.1523, -0.1089, and -0.1866) and dried fruit intake (Rg = -0.2187, -0.1639, and -0.2623). Local analyses further identified multiple chromosomal regions with shared genetic signals. Finally, condFDR/conjFDR analyses supported these overlaps and enabled the identification of several significant shared loci between PS and the dietary traits. Conclusion: This study systematically investigated the genetic associations between PS and three dietary intake patterns from a genomic perspective and characterized their genome-wide and local genetic overlap. The shared loci identified enhance the understanding of nutrition-disease molecular mechanisms and provide genetic evidence to inform future mechanistic research and risk-modification strategies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.