Observational studyBalkan medical journal2026
Association of Time-to-Peak of Renal Blood Flow with Outcomes in Heart Failure: An Exploratory Comparative Analysis with Conventional Predictors.
Observational study in Balkan medical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Background: Time-to-peak of renal blood flow (TTPr), derived from Tc-99m diethylenetriaminepentaacetic acid (DTPA) renal scintigraphy, is a novel parameter for assessing renal perfusion. Aims: To evaluate the prognostic significance of TTPr in patients with heart failure (HF). Study Design: Retrospective, observational cohort study. Methods: We analyzed 304 patients with HF who underwent Tc-99m DTPA renal scintigraphy to assess TTPr. TTPr values were compared between deceased and surviving patients. Cox regression analyses evaluated the prognostic value of TTPr. Model performance was assessed using the C-index, net reclassification improvement (NRI), and integrated discrimination improvement (IDI). Bootstrap internal validation (200 repetitions) generated optimism-corrected estimates, and the Holm-Bonferroni correction accounted for multiple testing in secondary analyses. Results: During a median follow-up of 790 days, 79 patients (26.0%) died. For short-term outcomes (3-month mortality, n = 7), deceased patients showed a trend toward prolonged TTPr compared with survivors (59 s vs. 27 s, Conclusion: Time-to-peak of renal blood predicted long-term outcomes in this HF cohort, showing potential incremental value. Prospective validation in broader populations is warranted before clinical implementation.
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