Evidence map›Paper›PMID 41885174›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Smartly Assembled near-Micron RF-Responsive Agents Bridge Transarterial Embolization and Immunothermal Potentiation.

Qitao Hu, Junkang Ding, Lingxiao Zhang, Zhou Tian, Cheng Zeng, Shaomin Zou, Wenjing Zhang, Tangye Zeng, Zhencang Gao, Zhouyi Sun and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Qitao HuDepartment of Surgery, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.ORCID 0009-0006-4287-1834
Junkang DingDepartment of Surgery, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.
Lingxiao ZhangInterdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark.
Zhou TianDepartment of Surgery, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.
Cheng ZengDepartment of Surgery, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.
Shaomin ZouDepartment of Surgery, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.
Wenjing ZhangDepartment of Surgery, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.
Tangye ZengDepartment of Surgery, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.
Zhencang GaoDepartment of Surgery, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.
Zhouyi SunDepartment of Surgery, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.
Gang LiuState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China.
Weiyu ChenDepartment of Respiratory and Critical Care Medicine, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.ORCID 0000-0003-4436-2743
Zhe TangDepartment of Surgery, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.

Funding

"Pioneer" and "Leading Goose" R&D Program of Zhejiang 2025C02132The Zhejiang Province Vanguard Goose-Leading Initiative 2025C01114
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) remains a significant clinical challenge due to the limited efficacy of conventional treatments like surgery, radiofrequency ablation (RFA), and transarterial embolization (TAE). Here, we develop an innovative TAE and immunothermal therapy strategy based on smartly assembled near-micron layered double hydroxide particles co-loaded with STING agonist (NM-LDHs-cGP). By smartly responding to local charge fluctuations and microenvironmental changes, NM-LDHs undergo self-assembly and hierarchical stacking to form stable vascular embolic agents, thereby achieving superior embolization efficacy and excellent responsiveness to radiofrequency-induced thermal stimulation. NM-LDHs-cGP activates the cGAS-STING pathway, promotes dendritic cell maturation, and elicits robust CD8

Indexed as

Carcinoma, HepatocellularEmbolization, TherapeuticHyperthermia, InducedImmunotherapyLiver NeoplasmsRadiofrequency AblationAnimalsCell Line, TumorcGAS-STING Signaling PathwayHumansMicecombined immunotherapyhepatocellular carcinomanear‐micron nanomedicineradiofrequency ablationtransarterial embolization

Identifiers

PMID41885174
PMCPMC13587982

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.