Evidence map›Paper›PMID 41885253›Full record

ArticleGlia2026

Microglial Inhibition Promotes Proliferation and Differentiation of Neural Stem Cells via STAT3/SDF-1/CXCR4 Signaling Pathway in Hypoxic-Ischemic Encephalopathy.

Ao Ding, Guiqin Duan, Mingwei Zhu, Li Chen, Jie Luo, Ting Tan, Zilin Li, Wenhui Wang, Jun Wang, Yuan Chen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Glia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ao DingNeurobiology Research Center, School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, China.
Guiqin DuanDepartment of Child Health, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Mingwei ZhuGuangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Li ChenGuangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Jie LuoGuangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.ORCID 0000-0002-0791-1419
Ting TanGuangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Zilin LiNeurobiology Research Center, School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, China.
Wenhui WangNeurobiology Research Center, School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, China.
Jun WangDepartment of Child Health, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yuan ChenNeurobiology Research Center, School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, China.
Ya-Ping TangGuangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.

Funding

Guangzhou Health Care Cooperative Innovation Major Project 201704020221Key Scientific and Technological Project of Guangdong Province 2018B030335001Key Scientific and Technological Project of Guangzhou City 202007030002Key Technologies R&D Program of Sichuan Province of China 14ZC0054the National Natural Science Foundation of China (NSFc) 31671098the National Natural Science Foundation of China (NSFc) 81620108021the Natural Science Foundation of Guangdong Province 2022A1515012506
6 · The paper itself

Abstract

Neonatal hypoxic-ischemic encephalopathy (HIE) may induce substantial neuronal damage. In particular, an overactivation of microglia following HIE represents a pathogenically important process. Previous studies have shown that microglial inhibitors can exert neuroprotective effects in HIE; however, the specific mechanisms underlying these effects have not yet been elucidated. Ligation of the left common carotid artery and exposure to 5% O

Indexed as

Cell DifferentiationCell ProliferationHypoxia-Ischemia, BrainMicrogliaNeural Stem CellsAnimalsAnimals, NewbornAnisolesDisease Models, AnimalMalePyrimidinesRatsRats, Sprague-DawleyReceptors, CXCR4Signal TransductionSTAT3 Transcription Factor5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamineAnisolesCxcr4 protein, ratPyrimidinesReceptors, CXCR4Stat3 protein, ratSTAT3 Transcription FactorGW2580hypoxic–ischemic encephalopathymicrogliamicroglial inhibitionneural stem cellsSTAT3 signaling pathway

Identifiers

PMID41885253
PMCPMC13019663

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.