Evidence map›Paper›PMID 41885390›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

SMAD4 Palmitoylation Drives a Metabolic-Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer.

Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yang WangDepartment of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.ORCID https://orcid.org/0009-0002-2204-6053
Shan ZhangDepartment of Stomatology, Shanghai Tenth People's Hospital, Tongji University Cancer Center, Shanghai, China.
Junping BaiDepartment of Stomatology, Shanghai Tenth People's Hospital, Tongji University Cancer Center, Shanghai, China.
Xiaobing LiCenter For Molecular Recognition and Biosensing, School of Life Sciences, Shanghai University, Shanghai, China.
Yi HanDepartment of Stomatology, Shanghai Tenth People's Hospital, Tongji University Cancer Center, Shanghai, China.
Min JiYangPu District Mental Health Center, Shanghai University of Medicine & Health Sciences, Shanghai, China.
Chongyi JiangDepartment of Hepato-Biliary-Pancreatic Surgery, Huadong Hospital, Fudan University, Shanghai, China.
Xiaobei GeDepartment of Nursing, Huadong Hospital, Fudan University, Shanghai, China.
Tianyu YuHepatobiliary Surgery Center, Shanghai Tongji Hospital Affiliated to Tongji University, Tongji University, Shanghai, China.
Yongying HouDepartment of Pathology, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Jun ZhangInternational Cancer Center, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Department of Biochemistry and Molecular Biology, Shenzhen University Medical School, Shenzhen, China.
Wangting LiSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China.
Yiran SongDepartment of Gastroenterology, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Jiaying CaiDepartment of Gastroenterology, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Yingqun ZhouDepartment of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Liwei AnDepartment of Stomatology, Shanghai Tenth People's Hospital, Tongji University Cancer Center, Shanghai, China.
Feng WangYangPu District Mental Health Center, Shanghai University of Medicine & Health Sciences, Shanghai, China.ORCID https://orcid.org/0000-0003-4068-3339

Funding

Cultivation Grant for Clinical and Basic Integration Research of Shanghai Tenth People's Hospital SYYYRH2025021National Natural Science Foundation of China Grants 82573553Noncommunicable Chronic Diseases-National Science and Technology Major Project 2024ZD0533203Science and Technology Commission of Shanghai Municipality 23YF1432900Science and Technology Commission of Shanghai Municipality 23ZR1480400Shanghai Academic/Technology Research Leader 23XD1433000Shanghai Oriental Talent program BJWS2024032
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is characterized by frequent SMAD4 inactivation and profound lipid metabolic rewiring, yet how these processes intersect especially in SMAD4

Indexed as

CarcinogenesisCarcinoma, Pancreatic DuctalLipoylationPancreatic NeoplasmsRadiation ToleranceSmad4 ProteinAnimalsCell Line, TumorHumansMiceSmad4 ProteinSMAD4 protein, humanFASNpalmitic acidpalmitoylationpancreatic cancerradiotherapySMAD4

Identifiers

PMID41885390
PMCPMC13325641

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.