Evidence map›Paper›PMID 41886217›Full record

ArticleGeroScience2026

Interactive effects of retinal biomarkers and sleep on cognition: longitudinal evidence from community-dwelling older adults.

Ting-Wen Chu, Yi-Ting Hsieh, Jeng-Min Chiou, Yao-Lin Liu, Yen-Ching Chen, Jen-Hau Chen

Abstract read
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In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ting-Wen ChuInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Yi-Ting HsiehDepartment of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.
Jeng-Min ChiouInstitute of Statistics and Data Science, National Taiwan University, Taipei, Taiwan.
Yao-Lin LiuDepartment of Ophthalmology, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
Yen-Ching ChenInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan. karenchen@ntu.edu.tw.ORCID http://orcid.org/0000-0002-8159-7202
Jen-Hau ChenDepartment of Geriatrics and Gerontology, National Taiwan University Hospital Yunlin Branch, Yunlin County, Taiwan. jhhchen@ntu.edu.tw.ORCID http://orcid.org/0000-0002-7141-1582

Funding

National Science and Technology Council 100-2314-B-002-103National Science and Technology Council 101-2314-B-002-126-MY3National Science and Technology Council 103-2314-B-002-033-MY3National Science and Technology Council 104-2314-B-002-038-MY3National Science and Technology Council 107-2314-B-002-186-MY3National Science and Technology Council 107-2314-B-002-230National Science and Technology Council 108-2314-B-002-128-MY2National Science and Technology Council 110-2314-B-002-068National Science and Technology Council 110-2314-B-002-129-MY3National Science and Technology Council 111-2314-B-002-090-MY3National Science and Technology Council 113-2314-B-002-188-MY3National Science and Technology Council 114-2314-B-002 -062 -MY3
6 · The paper itself

Abstract

Retinal thickness has been proposed as a non-invasive biomarker of neurodegeneration, whereas sleep disturbances represent modifiable risk factors for cognitive impairment. However, the combined and temporal associations of these factors with cognition remain unclear. This prospective cohort study (2015-2022) included 257 participants aged ≥ 65 years. The retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GC-IPL) thickness, sleep variable (sleep quality and daytime sleepiness) were assessed at baseline. Cognitive performance, including global and domain-specific measures, was evaluated at baseline and biennially. Longitudinal associations and interaction effects were evaluated using multilevel generalized linear mixed models, with particular attention to quadrant-level variations. Elevated RNFL thickness was associated with better global cognition over time (

Indexed as

Cognitive impairmentGanglion cell-inner plexiform layerOlder adultsOptical coherence tomographyRetinaRetinal nerve fiber layerSleep

Identifiers

PMID41886217

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.