ArticleProbiotics and antimicrobial proteins2026
Strain-Specific Effects of three Different Native Lactobacillus on Anthropometric Indices, Appetite, and Nesfatin-1 in Obese Adults: A Triple-Blind Randomized Clinical Trial.
Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Obesity is a multifactorial metabolic disorder often accompanied by gut dysbiosis. Probiotics may restore microbial balance and modulate metabolic and appetite-regulating pathways. Therefore, the present study investigated the strain-specific effects of three native Lactobacillus species on anthropometric indices, appetite, and nesfatin-1 concentrations in obese adults. In this triple-blind, randomized, placebo-controlled clinical trial, 100 obese adults (BMI 30–40 kg/m², aged 18–60 years) were allocated into four groups to receive one sachet daily of L. plantarum (2 × 10⁹ CFU), L. fermentum (2 × 10⁹ CFU), L. rhamnosus (2 × 10⁹ CFU), or placebo for 60 days. Anthropometric indices—including BMI, waist circumference (WC), waist-to-height ratio (WHtR), body roundness index (BRI), a body shape index (ABSI), lipid accumulation product (LAP), and visceral adiposity index (VAI)—were evaluated. A validated Likert-scale questionnaire assessed appetite, and serum nesfatin-1 levels were measured using ELISA. Eighty-nine participants completed the trial. After adjustment for age, sex, and baseline values, L. fermentum supplementation significantly reduced WC (P = 0.049) and BRI (P = 0.048) compared with placebo. Within-group analysis revealed that L. plantarum and L. fermentum significantly decreased WC, WHtR, and BRI (P < 0.05). Both strains also produced significant reductions in appetite scores (P = 0.004 and P < 0.001, respectively). No statistically significant changes in serum nesfatin-1 levels were detected among groups. Supplementation with native L. fermentum and L. plantarum for 60 days improved some anthropometric parameters and appetite in obese adults, independent of significant nesfatin-1 modulation. These findings highlight the strain-specific potential of native probiotics as adjunctive strategies for obesity management. However, future well-designed clinical research with a larger sample and/or extended follow-up is suggested to confirm this evidence.Trial registration: IRCT, IRCT20220608055106N1, Registered 3 July 2022
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