ArticleAmerican journal of physiology. Heart and circulatory physiology2026
Associations of urinary isoprostanes with structural and load-dependent arterial stiffness: the Multi-Ethnic Study of Atherosclerosis.
Theodore M DeConne, Petra Buzkova, Ryan Pewowaruk, Bruce M Psaty, Adam D Gepner, Joseph A Delaney, Timothy M Hughes, Nels C Olson
Abstract readMulticenter Study
In one paragraphArticle in American journal of physiology. Heart and circulatory physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Theodore M DeConneDepartment of Internal Medicine, Section of Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States.ORCID 0000-0002-9704-6499 Petra BuzkovaDepartment of Biostatistics, University of Washington, Seattle, Washington, United States.
Ryan PewowarukRyan Pewowaruk Research Consulting, Madison, Wisconsin, United States.
Bruce M PsatyCardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Systems and Population Health, University of Washington, Seattle, Washington, United States.
Adam D GepnerDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States.ORCID 0000-0002-5869-2850 Joseph A DelaneyDepartment of Medicine, University of Washington, Seattle, Washington, United States.ORCID 0000-0003-1771-1776 Timothy M HughesDepartment of Internal Medicine, Section of Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States.
Nels C OlsonDepartment of Pathology and Laboratory Medicine, University of Vermont Larner College of Medicine, Burlington, Vermont, United States.ORCID 0000-0003-1192-9969 Funding
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MSubclinical Vascular Contributions to Alzheimer's Disease: The Multi-Ethnic Study of Atherosclerosis (MESA) Multisite Study of AD (Renewal)R01AG058969 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Timothy M. Hughes, YONGMEI LIU · 2018 to 2026
$33.4MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MWake Forest University School of Medicine Alzheimer's Disease Research CenterP30AG072947 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SHANNON L RISACHER · 2021 to 2026
$24.3MTask Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2MTask Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1MTO EXERCISE OPTION PERIOD ONE (1) FOR TASK AREA A - MESA CORE OPERATIONS, FIELD CENTER.75N92020D00004 · NHLBI · NORTHWESTERN UNIVERSITY · PI SIEGEL, JONATHAN H · 2020 to 2025
$4.5MTask Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00006 · NHLBI · UNIVERSITY OF MINNESOTA · PI PANKOW, JAMES S · 2020 to 2025
$4.4MTask Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00003 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI POST, WENDY S · 2020 to 2025
$3.8MTranslational Training in Aging and Alzheimer’s Disease Related DisordersT32AG033534 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI STEPHEN B. KRITCHEVSKY · 2009 to 2026
$3.6MTask Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00007 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BERTONI, ALAIN GERALD · 2020 to 2025
$3.5MAmerican Heart Association (AHA) 16SFRN27870000HHS | NIH | National Center for Advancing Translational Sciences (NCATS) UL1-TR-000040HHS | NIH | National Center for Advancing Translational Sciences (NCATS) UL1-TR-001079HHS | NIH | National Center for Advancing Translational Sciences (NCATS) UL1-TR-001420HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95159HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95160HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95161HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95162HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95163HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95164HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95165HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95166HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95167HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95168HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95169HHS | NIH | National Institute on Aging (NIA) R01AG058969HHS | NIH | National Institute on Aging (NIA) T32AG033534NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS HHSN268201500003INHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NIA NIH HHS P30 AG072947NIA NIH HHS R01 AG058969NIA NIH HHS T32 AG033534
6 · The paper itselfAbstract
Total carotid pulse wave velocity (T-PWV), a measure of arterial stiffness, is caused by structural (S) remodeling and elevated blood pressure exerting a pressure-load on the arterial wall. Isoprostanes are oxidative stress biomarkers that have been associated with arterial stiffness. We sought to investigate the cross-sectional and longitudinal associations of urinary 8-isoprostane (iPF2α-III) and its metabolite (iPF2α-III-M), measured at a single timepoint at baseline, with carotid T-PWV, S-PWV, and load-dependent (LD)-PWV in a subset (
Indexed as
AtherosclerosisDinoprostVascular StiffnessAgedAntihypertensive AgentsBiomarkersCross-Sectional StudiesFemaleHumansHypertensionLongitudinal StudiesMaleMiddle AgedOxidative StressPulse Wave AnalysisRisk Factors8-epi-prostaglandin F2alphaAntihypertensive AgentsBiomarkersDinoprostarterial stiffnessepidemiologyisoprostanesoxidative stressrisk factors
Identifiers
PMID41886287
PMCPMC13123638
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