SynthesisPoultry science2026
Grapes and their by-products effects on growth performance, intestinal histomorphology, immune response and antioxidant status in broiler chickens - A meta-analysis.
Synthesis in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Tiny but Mighty: A Low Dose of Standardized Dry Grape Extract Potentiates Antioxidant Defenses in Broiler Chickens.Antioxidants (Basel, Switzerland) · 2026Article
- Effects of Fermented Grape Seed in Breeding-Pigeon Diets on Growth Performance, Immune Responses, and Oxidative Status of Offspring Squabs.Animals : an open access journal from MDPI · 2026Article
- Efficacy of yeast and yeast-derived products on growth performance and intestinal morphology of broiler chickens: a meta-analysis.Poultry science · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A comprehensive meta-analysis was conducted to quantitatively assess the impact of dietary grape and grape by-products supplementation on growth performance, intestinal histomorphology, immunological response, and antioxidant status in broiler chickens. A systematic search guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 across PubMed, Scopus, and Web of Science up to October 19, 2025, yielded 349 records, of which 21 controlled feeding studies satisfied the inclusion criteria. Data were analyzed using a multilevel random-effects model in R (metafor package). Heterogeneity (I² and τ²) and publication bias were evaluated using Egger's regression and the trim-and-fill method. Pooled estimations indicated that grape supplementation did not significantly influence body weight gain (mean difference (MD) 12.7 g, 95% CI: -14.5 to 39.8, P = 0.360), feed intake (MD = 30.6 g, 95% CI: -51.8 to 113, P = 0.466), or feed conversion ratio (FCR) (MD = 0.01, 95% CI: -0.01 to 0.02, P = 0.565). Significant enhancements were observed in villus height (MD = 59.5 µm, 95% CI: 1.49-117, P = 0.044), reduction in crypt depth (MD = -13.3 µm, 95% CI: -18.7 to -7.95, P < 0.001), and villus height-to-crypt depth ratio (VH:CD) (MD = 1.31, 95% CI: 0.32-2.29, P = 0.009), indicating improved intestinal histomorphology and absorptive capacity. The humoral immune response showed a positive but non-significant effect (standardized mean difference (SMD) = 1.09, 95% CI: -0.69-2.87, P = 0.228). Enzymatic antioxidants (SMD = 0.25, P = 0.697), lipid peroxidation (SMD = -0.50, P = 0.297), and non-enzymatic antioxidant capacity (SMD = 2.45, P = 0.26) were also non-significant. Substantial heterogeneity across outcomes was mainly explained by grape product form, intestinal segment, immunological outcome type, and antioxidant marker type through meta-regression. Overall, grape by-products improved intestinal histomorphology but did not significantly enhance growth performance, immunity, or oxidative balance.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.