Evidence map›Paper›PMID 41887688›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2026

[Esketamine alleviates depression-like behaviors in mice with chronic restraint stress by activating glutamatergic neurons in the medial prefrontal cortex].

Zhuoning Zhang, Xinyu Hao, Fuyang Cao, Yongxin Guo, Shuting Guo, Chen Cai, Weidong Mi, Li Tong

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhuoning ZhangDepartment of Anesthesia, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
Xinyu HaoDepartment of Anesthesia, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
Fuyang CaoDepartment of Anesthesia, Sixth Medical Center of Chinese PLA General Hospital, Beijing 100048, China.
Yongxin GuoDepartment of Anesthesia, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
Shuting GuoDepartment of Anesthesia, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
Chen CaiDepartment of Anesthesia, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
Weidong MiDepartment of Anesthesia, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
Li TongDepartment of Anesthesia, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.

Funding

National Natural Science Foundation of China 82171180
6 · The paper itself

Abstract

objectivesTo investigate the regulatory role of glutamatergic neurons in the medial prefrontal cortex (mPFC) in the antidepressant effects of esketamine.

methodsA total of 150 male C57BL/6J mice were randomly divided into 15 groups (

resultsCompared with saline-treated CRS mice, the mice with esketamine treatment showed significantly reduced immobility time in TST and FST and increased sucrose preference rate. Immunofluorescence staining revealed significantly increased expression of c-Fos in glutamatergic neurons in esketamine-treated mice. Chemogenetic activation of mPFC glutamatergic neurons (hM3Dq group) significantly decreased immobility time of the mice in the TST and FST and increased their sucrose preference as compared with the mice in mCherry group (

conclusionsEsketamine produces antidepressant effects in mice with CRS by activating glutamatergic neurons in the mPFC.

Indexed as

DepressionKetamineNeuronsPrefrontal CortexStress, PsychologicalAnimalsAntidepressive AgentsBehavior, AnimalGlutamic AcidMaleMiceMice, Inbred C57BLProto-Oncogene Proteins c-fosRestraint, PhysicalAntidepressive AgentsEsketamineGlutamic AcidKetamineProto-Oncogene Proteins c-fosdepressionesketamineglutamatergic neuronsmedial prefrontal cortex

Identifiers

PMID41887688
PMCPMC13021346

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.