ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2026
[Mefloquine HCl promotes DNA repair and alleviates radiation-induced lung epithelial cell injury].
Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo investigate the protective effect of mefloquine HCl (MQ) against X-ray irradiation-induced DNA damage in lung epithelial cells.
methodsHuman lung epithelial cells (BEAS-2B) were divided into blank control group, irradiation group, and irradiation+MQ treatment group. The effects of MQ on cell proliferation and radiosensitivity after X-ray irradiation were assessed using CCK-8 assay, EdU-488 assay, and colony formation assay. Apoptosis and cell cycle distribution of BEAS-2B cells with different treatments were detected by flow cytometry. The effect of MQ in promoting DNA double-strand break (DSB) repair was observed using immunofluorescence staining and comet assay, and the molecule ar mechanism was explored using Western blotting, qPCR, and luciferase reporter assays.
resultsMQ at 0-10 μmol/L did not significantly affect BEAS-2B cell viability. Compared to the irradiated cells, treatment with 0-10 μmol/L MQ enhanced the cell viability, and the effect was the most conspicuous at 10 μmol/L. MQ treatment obviously promoted proliferation and increased clonogenic survival rate of irradiated BEAS-2B cells while reducing their radiosensitivity, and significantly lowered cell apoptosis rate following the irradiation. Cell cycle analysis revealed that MQ alleviated G2/M phase arrest induced by irradiation, and comet assay and immunofluorescence staining showed reduced comet tail moment and γH2AX foci formation in irradiation+MQ group. Western blotting and qPCR demonstrated that MQ treatment for 48 h significantly increased CtIP promoter activity and upregulated CtIP expressions at both the mRNA and protein levels.
conclusionsMQ promotes DSB repair in BEAS-2B cells by upregulating CtIP expression and may thus alleviate radiation-induced lung epithelial cell injury.
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