Evidence map›Paper›PMID 41887695›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2026

[A nomogram model for predicting MACE risk following primary percutaneous coronary intervention in STEMI patients: an exploratory study based on serum GSDMD].

Xinyi Hu, Weijian Wang, Hui Li, Zongzheng Chen, Xin Zhou, Junfei Yuan, Liang Chen

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Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Xinyi HuWuxi Clinical College of Anhui Medical University, Wuxi 214044, China.
Weijian WangDepartment of Cardiovascular Medicine.
Hui LiSecond Clinical School of Anhui Medical University, Hefei 230032, China.
Zongzheng ChenDepartment of Cardiovascular Medicine.
Xin ZhouWuxi School of Medicine, Jiangnan University, Wuxi 214122, China.
Junfei YuanWuxi School of Medicine, Jiangnan University, Wuxi 214122, China.
Liang ChenWuxi Clinical College of Anhui Medical University, Wuxi 214044, China.

Funding

National Natural Science Foundation of China 82000420
6 · The paper itself

Abstract

objectivesTo investigate the value of serum gasdermin D (GSDMD) level for predicting 30-day major adverse cardiovascular events (MACE) in patients following primary percutaneous coronary intervention (PPCI) for acute ST-segment elevation myocardial infarction (STEMI) and construct a predictive nomogram.

methodsA total of 100 STEMI patients undergoing PPCI were prospectively enrolled. Serum GSDMD levels of the patients were measured by ELISA before and on the second morning after PPCI and compared using Wilcoxon signed-rank test. The patients were divided into high-GSDMD and low-GSDMD groups based on the optimal cut-off value of postoperative GSDMD levels determined by the Youden index. During the 30-day follow-up, the patients were categorized into MACE group (

resultsPost-PPCI serum GSDMD levels were significantly elevated relative to the pre-PPCI levels (

conclusionsElevated post-PPCI serum GSDMD level is an independent risk factor for 30-day MACE in STEMI patients. The nomogram model based on this biomarker provides a reliable tool for short-term risk stratification of these patients.

Indexed as

NomogramsPercutaneous Coronary InterventionPhosphate-Binding ProteinsST Elevation Myocardial InfarctionFemaleGasderminsHumansIntracellular Signaling Peptides and ProteinsMaleMiddle AgedProspective StudiesRisk FactorsGasderminsGSDMD protein, humanIntracellular Signaling Peptides and ProteinsPhosphate-Binding Proteinsgasdermin Dmajor adverse cardiovascular eventsprimary percutaneous coronary interventionpyroptosisST-segment elevation acute myocardial infarction

Identifiers

PMID41887695
PMCPMC13021348

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.