Evidence map›Paper›PMID 41887704›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2026

[Volatile oil from

Peng Feng, Jie Wang, Jiangwei Chu, Helin Wang, Yongyan Tian, Jiechang Zhang, Minglu Wang, Yutong Wang

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Peng FengMedical College, Hexi University, Zhangye 734000, China.
Jie WangMedical College, Hexi University, Zhangye 734000, China.
Jiangwei ChuMedical College, Hexi University, Zhangye 734000, China.
Helin WangMedical College, Hexi University, Zhangye 734000, China.
Yongyan TianMedical College, Hexi University, Zhangye 734000, China.
Jiechang ZhangMedical College, Hexi University, Zhangye 734000, China.
Minglu WangMedical College, Hexi University, Zhangye 734000, China.
Yutong WangMedical College, Hexi University, Zhangye 734000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the mechanism by which

methodsForty-eight 3-week-old SD rats were randomly divided into blank group (

resultsVOA treatment significantly reduced tic-like behavior scores and ameliorated striatal neuronal damage in the rat models, resulting also in lowered levels of TNF-α and C1q and increased levels of TGF-β and VEGF in both the serum and striatum, decreased mRNA and protein expression levels of TLR4, MyD88, and NF‑κB p65 in the striatum, and reduced nuclear translocation of NF‑κB p65. Immunofluorescence staining revealed significantly weakened expressions of Iba1 and CD86 and enhanced CD206 expression in the striatum of VOA-treated rats. All these ameliorative effects of VOA were significantly attenuated by treatment with TAK-242.

conclusionsVOA alleviates tic symptoms in rats by inhibiting microglia activation and polarization to reduce neuroinflammation possibly through suppression of the TLR4/MyD88/NF-κB signaling pathway.

Indexed as

AcorusMicrogliaOils, VolatileTic DisordersAnimalsDisease Models, AnimalMaleMyeloid Differentiation Factor 88NF-kappa BRatsRats, Sprague-DawleySignal TransductionToll-Like Receptor 4Myd88 protein, ratMyeloid Differentiation Factor 88NF-kappa BOils, VolatileTlr4 protein, ratToll-Like Receptor 4microgliatic disordersToll-like receptor 4/myeloid differentiation factor 88/nuclear factor kappa-B pathwayvolatile oil of Acorus tatarinowii Schott

Identifiers

PMID41887704
PMCPMC13021337

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.