Evidence map›Paper›PMID 41888425›Full record

ArticleMolecular psychiatry2026

Microbiota-Driven microglia reprogramming reverses depressive-like behaviors through Peripheral-to-Central immune crosstalk.

Jing Wu, Xingyu Zhou, Tiandong Luo, Xin Wang, Hongzhou Zuo, Ruijing Yang, Ruimin Tian, Yiyuan Wu, Yang Wu, Wenxia Jiang and 11 more

Abstract read
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In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Jing Wu *Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Xingyu Zhou *Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID http://orcid.org/0009-0003-1320-5603
Tiandong LuoDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Xin WangDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Hongzhou ZuoDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Ruijing YangDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Ruimin TianDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yiyuan WuDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yang WuDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Wenxia JiangDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yunpeng WangDepartment of Psychology, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0001-9831-1090
Jie YangDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yu HuangDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID http://orcid.org/0000-0003-2493-3879
Jianping ZhangDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yifan LiDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID http://orcid.org/0000-0003-1470-8862
Ping LiuDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Xunmin TanDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Minghao YuanDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Ma-Li WongDepartment of Psychiatry, College of Medicine, SUNY Upstate Medical University, Syracuse, NY, USA.
Julio LicinioDepartment of Psychiatry, College of Medicine, SUNY Upstate Medical University, Syracuse, NY, USA.
Peng ZhengDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. pengzheng_cqmu@yeah.net.ORCID http://orcid.org/0000-0002-9864-6832

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Major depressive disorder (MDD) is a major psychiatric condition associated with neuroimmune dysregulation. Microglia, the principal innate immune cells of the central nervous system, have been implicated in MDD. Nevertheless, the specific subpopulations involved and the mechanisms that govern their responses are still elusive. Here, we found that gut microbiota intervention using bedding from control non-stressed mice reverses chronic unpredictable mild stress (CUMS)-induced alterations in behavior. Using CD45

Indexed as

DepressionGastrointestinal MicrobiomeMicrogliaAnimalsBrainDisease Models, AnimalLeukocytes, MononuclearMajor Depressive DisorderMaleMiceMice, Inbred C57BLStress, Psychological

Identifiers

PMID41888425

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.