Evidence map›Paper›PMID 41888551›Full record

ArticleScientific reports2026

Sex-related differences in cardiovascular inflammation and metabolomics in a humanized transgenic mouse model of celiac disease.

Aline Pesi, Simon Lange, Fabian Schmitt, Manjusha Neerukonda, Michelle Wiegel, Theodora Petridou, Henning Ubbens, Lea Strohm, Dominika Mihalikova, Ivana Kuntic and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Aline Pesi *Institute of Translational Immunology and Research Center for Immunotherapy, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Simon Lange *Department of Cardiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Fabian SchmittInstitute of Immunology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Manjusha NeerukondaInstitute of Translational Immunology and Research Center for Immunotherapy, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Michelle WiegelInstitute of Translational Immunology and Research Center for Immunotherapy, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Theodora PetridouInstitute of Translational Immunology and Research Center for Immunotherapy, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Henning UbbensDepartment of Cardiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Lea StrohmDepartment of Cardiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Dominika MihalikovaDepartment of Cardiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Ivana KunticDepartment of Cardiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Marin KunticDepartment of Cardiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Philipp LurzDepartment of Cardiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
David LeistnerDepartment for Cardiology, Goethe University, Frankfurt, Germany.
Karin KeppelerDepartment of Cardiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Elena F VerduFarncombe Family Digestive Health Research Disease Institute, Department of Medicine, McMaster University, Hamilton, Canada.
Thierry SchmidlinInstitute of Immunology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Andreas DaiberDepartment of Cardiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Detlef SchuppanInstitute of Translational Immunology and Research Center for Immunotherapy, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Sebastian StevenDepartment of Cardiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany. steven@med.uni-frankfurt.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Celiac disease (CeD) is an immune-mediated disorder driven by dietary gluten, characterized by intestinal, such as diarrhoea and malabsorption, and many extraintestinal manifestations. Epidemiological studies have linked untreated CeD to an elevated risk of cardiovascular complications. In this study, CeD induced in humanized transgenic male NOD.DQ8 mice resulted in vascular dysfunction, cardiovascular oxidative stress, and systemic as well as vascular inflammation. In contrast, female NOD-DQ8 mice developed comparable CeD-specific small intestinal pathology upon gluten exposure but were protected from vascular dysfunction and cardiovascular inflammation. Compared with females, male CeD mice displayed pronounced dysregulation of cholesterol metabolism, activation of the kynurenine pathway, and mast cell activation in perivascular tissues. Pharmacological reduction of estrogen with the aromatase inhibitor letrozole partly impaired vascular dilatation in female CeD mice. These findings underscore the importance of considering sex-specific manifestations of CeD with its associated systemic inflammation in preclinical and clinical research.

Indexed as

Cardiovascular DiseasesCeliac DiseaseInflammationMetabolomicsAnimalsDisease Models, AnimalFemaleHumansMaleMiceMice, Inbred NODMice, TransgenicOxidative StressSex Factors

Identifiers

PMID41888551
PMCPMC13031320

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.