Evidence map›Paper›PMID 41888583›Full record

ArticleCommunications biology2026

PACS1 syndrome mutation disrupts dynein-mediated cargo transport via HDAC6 and BICD2.

Yunhan Yang, Laurel Thomas, Kun Chen, Sabrina Villar-Pazos, Wendy D Haffey, Andrew D'Agostino, Kayleigh Fanelli, You-Jin Choi, Vihaan Rathi, Maanas S Matlapudi and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yunhan YangDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Laurel ThomasDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID http://orcid.org/0009-0005-2718-2347
Kun ChenDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Sabrina Villar-PazosDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID http://orcid.org/0009-0005-7287-1846
Wendy D HaffeyDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0001-7957-280X
Andrew D'AgostinoDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Kayleigh FanelliDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-9272-9541
You-Jin ChoiDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Vihaan RathiDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Maanas S MatlapudiDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Kenneth D GreisDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0002-5316-3351
Gary ThomasDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. thomasg@pitt.edu.ORCID http://orcid.org/0000-0003-1976-7183

Funding

Molecular, Cellular and Behavioral Impact of the R203W PACS1 Syndrome MutationR01NS123649 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ANGELA M. GRONENBORN, Gary Thomas · 2022 to 2026
$3.3M
Impact of the E209K PACS2 Syndrome mutation on neuronal metabolism and neurotransmission.R01NS136370 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Gary Thomas · 2024 to 2026
$1.7M
NINDS NIH HHS R01 NS123649NINDS NIH HHS R01 NS136370U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS123649U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS136370
6 · The paper itself

Abstract

PACS1 syndrome is a neurodevelopmental disorder caused by a recurrent heterozygous missense mutation in PACS1 (p.R203W). We previously showed that PACS1

Indexed as

DyneinsHistone Deacetylase 6Microtubule-Associated ProteinsMutationVesicular Transport ProteinsGolgi ApparatusHumansMutation, MissenseProtein TransportBICD2 protein, humanDyneinsHDAC6 protein, humanHistone Deacetylase 6Microtubule-Associated ProteinsPACS1 protein, humanVesicular Transport Proteins

Identifiers

PMID41888583
PMCPMC13022394

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.