Evidence map›Paper›PMID 41888666›Full record

ArticleBMC plant biology2026

Multi-omics analysis reveals molecular mechanisms of maize responses to hexavalent chromium toxicity.

Huaisheng Zhang, Qianni Xie, Pingxi Wang, Xiangyuan Wu, Xining Jin, Dong Ding, Jiong Wan, Xiaoxiang Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC plant biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Huaisheng ZhangSchool of Agriculture, State Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, Henan Institute of Science and Technology, Xinxiang, 453003, China.
Qianni XieSchool of Agriculture, State Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, Henan Institute of Science and Technology, Xinxiang, 453003, China.
Pingxi WangSchool of Agriculture, State Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, Henan Institute of Science and Technology, Xinxiang, 453003, China.
Xiangyuan WuSchool of Agriculture, State Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, Henan Institute of Science and Technology, Xinxiang, 453003, China.
Xining JinSchool of Agriculture, State Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, Henan Institute of Science and Technology, Xinxiang, 453003, China.
Dong DingState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, College of Agronomy, Henan Agricultural University, Zhengzhou, 450046, China.
Jiong WanHenan Key Laboratory of Tea Plant Biology, College of Tea and Food Science, Xinyang Normal University, Xinyang, Henan, 464000, China. wan__jiong@163.com.
Xiaoxiang ZhangSchool of Agriculture, State Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, Henan Institute of Science and Technology, Xinxiang, 453003, China. zhangxx2020@hist.edu.cn.

Funding

High-level Talent Recruitment and Cultivation Project of Henan University of Science and Technology;Henan Agricultural University Open Research Project SKL2022KF10JointResearch on Agricultural Improved Seed of Henan Province 2022010204Shennong Laboratory First-rate Research Subject SN01-2022-02the Key Research and Development Project of Henan Province 241111114300the Key Scientific and Technological Research Project of Henan Province 252102110278the National Natural Science Foundation of China 32301772the Natural Science Foundation of Henan Province 262300422168
6 · The paper itself

Abstract

backgroundHexavalent chromium [Cr(VI)] is a highly toxic heavy metal that adversely affects plant growth and food safety. Here, we investigated the molecular responses of maize seedlings (hybrid Zhengdan958(ZD958) and parental lines Chang7-2(C72) and Zheng58(Z58)) to 20 mg/L Cr(VI) stress using transcriptomic and proteomic analyses.

resultsCr(VI) treatment induced 1226 commonly upregulated and 655 downregulated genes across all three genotypes, with upregulated genes enriched in stress- and defense-related processes (oxidative stress, xenobiotic response, hormone signaling) and downregulated genes associated with growth and development (cell wall biosynthesis, organ morphogenesis). Proteomic analysis showed similar patterns, highlighting key modules mediating Cr(VI) tolerance. Antioxidant genes (catalase3, glutaredoxin14, acco2, acco5) were significantly upregulated, indicating activation of ROS-scavenging pathways.

conclusionsThese results reveal coordinated transcriptional and proteomic responses that protect maize against Cr(VI)-induced oxidative stress while suppressing growth, providing candidate genes and pathways for breeding maize with enhanced tolerance to heavy metal-contaminated soils.

Indexed as

ChromiumZea maysGene Expression ProfilingGene Expression Regulation, PlantMultiomicsOxidative StressProteomicsSeedlingsTranscriptomeChromiumchromium hexavalent ionCr(VI) toxicityHeavy metal toleranceMaizeOxidative stress

Identifiers

PMID41888666
PMCPMC13141357

What Socratic holds

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.