ReviewCell communication and signaling : CCS2026
Mitochondrial interplay with membrane organelles in health and disease.
Review in Cell communication and signaling : CCS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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0 citing papers in PubMed.
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Authors and funding
4 authors.
Funding
Abstract
Mitochondria produce energy by oxidative phosphorylation to support vital physiological processes. In addition to energy production, they are essential for regulating calcium homeostasis, antioxidant defense, lipid metabolism, and programmed cell death pathways, including apoptosis and ferroptosis. Extensive physical and biochemical connections are established between mitochondria and other organelles, including the endoplasmic reticulum (ER), lipid droplets (LDs), lysosomes, peroxisomes, and endosomes. These dynamic inter-organelle interactions facilitate coordinated signaling and material exchange, ultimately shaping cellular metabolism and physiological response. Such functional integration ensures efficient energy distribution and robust quality control mechanisms. Disruptions in these interactions contribute to various pathological conditions, highlighting their biological significance. This review synthesizes the current understanding of mitochondrial crosstalk with membrane organelles, particularly the ER, LDs, lysosomes and endosomes, and explores their implications for health and disease. Deciphering these complex relationships in both physiological and pathological contexts provides mechanistic insights and reveals potential therapeutic strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.