SynthesisWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
The Healing Effect of Photobiomodulation on Venous Leg Ulcers: A Systematic Review and Meta-Analysis.
Synthesis in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
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Abstract
Venous leg ulcers are common, costly and often slow to heal despite standard management. Photobiomodulation has been proposed as an adjuvant therapy to enhance wound repair. This systematic review and meta-analysis aimed to evaluate the effect of photobiomodulation on healing outcomes in venous leg ulcers. A comprehensive search of PubMed, Embase, Web of Science and Cochrane Library (1990-2024) identified randomised controlled trials evaluating photobiomodulation in adults with venous leg ulcers. Two reviewers independently screened studies (n = 3824) and assessed eligibility according to predefined inclusion and exclusion criteria (n = 34). Data were extracted from the included studies (n = 11), and the risk of bias was assessed using the Cochrane RoB 2 tool. A random-effects meta-analysis was conducted for the absolute change in ulcer area. Eleven trials were included, comprising 615 randomised patients, where 340 had venous leg ulcers. Patients who completed follow-up contributed to the healing outcomes (intervention n = 169, controls n = 167). All studies were evaluated to have some or high concerns for risk of bias. Four trials contributed data to the meta-analysis showing that photobiomodulation did not significantly reduce ulcer area compared with controls (Mean Difference 3.77 cm
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.