Evidence map›Paper›PMID 41889113›Full record

ReviewComprehensive Physiology2026

Adventitial Niches, Complement and Inflammation in Pulmonary Vascular Disease: Current Status and Future Directions.

Hui Zhang, Ram Raj Prasad, Sushil Kumar, Min Li, Dallas Jones, Cheng-Jun Hu, Claudia Mickael, Yen-Rei Yu, Rubin M Tuder, Kurt R Stenmark

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Comprehensive Physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hui ZhangDepartment of Pediatrics and Medicine, Cardiovascular and Pulmonary Research Laboratroy (CVP), University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Ram Raj PrasadDepartment of Pediatrics and Medicine, Cardiovascular and Pulmonary Research Laboratroy (CVP), University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Sushil KumarDepartment of Pediatrics and Medicine, Cardiovascular and Pulmonary Research Laboratroy (CVP), University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.ORCID 0000-0003-2290-2091
Min LiDepartment of Pediatrics and Medicine, Cardiovascular and Pulmonary Research Laboratroy (CVP), University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Dallas JonesDepartment of Pediatrics and Medicine, Cardiovascular and Pulmonary Research Laboratroy (CVP), University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Cheng-Jun HuDepartment of Craniofacial Biology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.
Claudia MickaelDepartment of Pediatrics and Medicine, Cardiovascular and Pulmonary Research Laboratroy (CVP), University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Yen-Rei YuDepartment of Pediatrics and Medicine, Cardiovascular and Pulmonary Research Laboratroy (CVP), University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Rubin M TuderDepartment of Pediatrics and Medicine, Cardiovascular and Pulmonary Research Laboratroy (CVP), University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Kurt R StenmarkDepartment of Pediatrics and Medicine, Cardiovascular and Pulmonary Research Laboratroy (CVP), University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Funding

Role of Complement-Driven Pulmonary Vascular Inflammation in PHP01HL152961 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI DELANEY, CASSIDY A · 2020 to 2024
$14.1M
Translational Pulmonary Vascular Biology ProgramT32HL007171 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Sonia Castro Flores, Tim Lahm · 1985 to 2026
$9.4M
NHLBI NIH HHS P01HL152961NHLBI NIH HHS T32HL007171
6 · The paper itself

Abstract

There is strong evidence supporting inflammatory and autoimmune processes in the pathogenesis of pulmonary arterial hypertension (PAH), although the initiating and disease-sustaining mechanisms remain unclear. Studies in arthritis, kidney disease, and cancer have demonstrated that dysregulation of the complement system can drive inflammation-mediated tissue injury. We have shown that activation of the complement cascade, particularly the alternative pathway, within the pulmonary vasculature is a key driver of proinflammatory responses in pulmonary hypertension (PH). Single-cell spatial transcriptomic analysis of PAH lungs further revealed complement-rich adventitial fibroblasts, granzyme K (GZMK)

Identifiers

PMID41889113
PMCPMC13022472

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.