Evidence mapPaperPMID 41889133Full record

ArticlePhytotherapy research : PTR2026

Isoquercitrin Improves Renal Tubular Epithelial Cell Mitochondrial Dysfunction by Regulating Extracellular Signal-Regulated Kinase/Reactive Oxygen Species Signaling and Connexin 43 Expression in Diabetic Kidney Disease.

Qi Wu, Yupeng Tao, Chenchen Sun, Yijing Li, Tianyu Liu, Buhui Liu, Wei Li, Kun Gao, Yao Zhou

Abstract read
In one paragraph

Article in Phytotherapy research : PTR, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qi WuDepartment of Physiology, School of the Basic Medicine, Xuzhou Medical University, Xuzhou, China.
Yupeng TaoDepartment of Pathophysiology, School of the Basic Medicine, Xuzhou Medical University, Xuzhou, China.
Chenchen SunFirst Clinical Medical College, Xuzhou Medical University, Xuzhou, China.
Yijing LiFirst Clinical Medical College, Xuzhou Medical University, Xuzhou, China.
Tianyu LiuFirst Clinical Medical College, Xuzhou Medical University, Xuzhou, China.
Buhui LiuDepartment of Anatomy, School of the Basic Medicine, Xuzhou Medical University, Xuzhou, China.
Wei LiDivision of Nephrology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Kun GaoDivision of Nephrology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Yao ZhouDepartment of Pathophysiology, School of the Basic Medicine, Xuzhou Medical University, Xuzhou, China.ORCID https://orcid.org/0000-0002-2845-6339

Funding

Jiangsu Province Leading Talents Cultivation Project for Traditional Chinese Medicine SLJ0323Jiangsu Province Traditional Chinese Medicine Technology Development Plan QN202427Jiangsu Training Program of Innovation and Entrepreneurship for Undergraduates 202410313010ZNational Natural Science Foundation of China 82474473Natural Science Foundation of Jiangsu Province BK20241042
6 · The paper itself

Abstract

Isoquercitrin (IQ) is a natural flavonoid compound with potent anti-inflammatory and antioxidant effects; its role and mechanism of action in diabetic kidney disease (DKD) are unclear. This study clarified the role of IQ in delaying DKD and regulating tubular epithelial cell lipid metabolism. db/db mice were randomly divided into DKD, low-dose IQ, high-dose IQ, and dapagliflozin groups. C57BL/6J mice were used as controls. NRK-52E cells and connexin 43 (Cx43) knockdown (Cx43

Indexed as

Connexin 43Diabetic NephropathiesExtracellular Signal-Regulated MAP KinasesMitochondriaQuercetinReactive Oxygen SpeciesAnimalsCell LineCell SurvivalEpithelial CellsKidney TubulesLipid MetabolismMaleMiceMice, Inbred C57BLOxidative StressConnexin 43Extracellular Signal-Regulated MAP KinasesisoquercitrinQuercetinReactive Oxygen Speciesconnexin 43diabetic kidney diseaseIsoquercitrinlipid metabolismmitochondrial function

Identifiers

PMID41889133
PMCPMC13436248

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.