Evidence map›Paper›PMID 41889290›Full record

ArticleProteomics2026

Mass Spectrometry Proteomics of the Nanoparticle Corona Is Highly Dependent on Sample Preparation Protocol.

Asia Saorin, Alberto Martinez-Serra, Michael Henry, Paula Meleady, Marco P Monopoli

Abstract read
In one paragraph

Article in Proteomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Asia SaorinChemistry Department, Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland.
Alberto Martinez-SerraChemistry Department, Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland.
Michael HenryLife Science Institute, Dublin City University, Dublin, Ireland.
Paula MeleadyLife Science Institute, Dublin City University, Dublin, Ireland.
Marco P MonopoliChemistry Department, Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland.

Funding

European Union's Research and Innovation 101092901Science Foundation Ireland Infrastructure Award SFI16/RI/3701
6 · The paper itself

Abstract

It is widely established that the layers of proteins bound to the surface of nanoparticles (NPs), also known as the protein corona, critically influence their behavior in biological environments. Despite numerous proteomics studies performed in different NP-corona systems, the impact of proteomic sample preparation methods on corona profiling remains poorly understood. In this study, we systematically compared five digestion protocols, namely S-Trap

Indexed as

Mass SpectrometryNanoparticlesProtein CoronaProteomicsHumansReproducibility of ResultsSilicon DioxideProtein CoronaSilicon Dioxidebiomolecular coronamass spectrometry proteomicsnanoparticle coronaprotein adsorptionsample preparation

Identifiers

PMID41889290
PMCPMC13106918

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.