ArticleFrontiers in medicine2026
Combined red blood cell distribution width and neutrophil-to-lymphocyte ratio and risk of composite cardiovascular events in patients with moderate-to-severe obstructive sleep apnea: a prospective cohort study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To evaluate the prognostic association of baseline red blood cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), and their combined index with 3-year composite cardiovascular events in moderate-to-severe obstructive sleep apnea (OSA) patients. Methods: This prospective cohort study enrolled 620 patients with moderate-to-severe OSA (AHI ≥ 15 events/h) from 2020-2022. Participants were categorized by baseline medians into low-risk (both low), intermediate-risk (one high), and high-risk (both high) groups. The primary outcome was composite cardiovascular events. Cox regression, ROC curves, NRI, and IDI assessed predictive performance. Results: During median follow-up of 36.2 months, 72 events occurred (11.6% rate). Each 1% increase in RDW (HR = 1.32, 95% CI: 1.15-1.52) and each 1-unit increase in NLR (HR = 1.41, 95% CI: 1.20-1.66) were independently associated with cardiovascular events (both Conclusion: The combined RDW-NLR index is a simple, accessible prognostic marker of cardiovascular events in moderate-to-severe OSA patients, providing additional risk stratification value beyond traditional risk factors for clinical risk stratification.
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