ArticleFrontiers in medicine2026
Association between hemoglobin variability and mortality in hemodialysis patients: a retrospective cohort study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Patients undergoing hemodialysis (HD) face high mortality rates. Monitoring specific laboratory parameters and their derivatives, including hemoglobin (Hb) and its variability, is crucial for improving clinical management and patient outcomes. However, the association between hemoglobin variability and mortality in HD patients remains controversial. Methods: A total of 652 HD patients treated at Wenzhou Traditional Chinese Medicine Hospital of Zhejiang Chinese Medical University were included based on predefined criteria. Patients were divided into survival group and death group based on mortality status during the study period for univariate analysis. Based on univariate results, the following parameters representing Hb variability (Hb-Var) were studied: Hb standard deviation (SD), Hb residual SD, Hb coefficient of variation (CV), and Hb abnormal ratio. Cut-off values for each parameter were determined using ROC curves. Patients were stratified into high-risk group and low-risk group based on these cut-off values. Survival analysis was performed using multivariable Cox regression to obtain hazard ratios (HRs) and Results: The results of univariate analysis showed that there were statistically significant differences in age ( Conclusion: Hb-Var included Hb abnormal ratio, Hb residual SD and Hb CV are independent factors associated with mortality in hemodialysis patients.
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