ArticleFrontiers in microbiology2026
Identification of disease ameliorated metabolite candidates from Gut Microbes and their interacting targets based on a novel estimating function.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The gut microbiota plays a crucial role in human health and the progression of diseases. As key mediators of the interactions between gut microbiota and host diseases, metabolite changes have a significant influence on disease development and progression. However, without experimental validation by metabolomics, identifying the level of metabolite changes in specific diseases remains challenging. For this reason, we devised a scoring function to quantitatively estimate metabolite changes across disease phenotypes by integrating changes in the relative abundance of gut microbes owning these metabolites, and hereby developed the online repository to reserve these associations of metabolites and diseases. The consequent GMMAD with v2.0 currently contains 83 diseases and 6966 metabolites. Among them, 85,136 associations are of statistical significance (paired-sample
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