ArticleJACS Au2026
A Biomimetic Self-Adjuvanting Glycoprotein Vaccine Platform Elicits Potent Antitumor Immunity against GD2-Positive Cancers.
Article in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The inherently low immunogenicity of tumor-associated carbohydrate antigens poses a significant obstacle to effective cancer immunotherapy. To address this challenge, we here report a biomimetic self-adjuvanting glycoprotein vaccine platform to elicit robust antitumor immunity against disialoganglioside GD2-positive cancers. This platform is constructed through the site-specific conjugation of a TLR4 agonist GAP112 (MPLA adjuvant analogue) to a carrier protein that is loaded with a chemoenzymatically synthesized GD2 glycan antigen. This precisely engineered "adjuvant-protein-antigen" conjugate is further incorporated into a biomimetic liposomal formulation to enhance its delivery and immune response. The resulting vaccine significantly enhanced lymph node migration and promoted both antigen uptake and maturation of antigen-presenting cells (APCs). Crucially, our vaccine elicited a potent GD2-specific IgG antibody response with markedly higher titers than those from an unconjugated mixture. Sera from immunized mice effectively bound to the target tumor cells and mediated potent complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC), demonstrating functional antitumor immunity. This versatile platform presents a powerful strategy for developing robust carbohydrate-based cancer vaccines, holding substantial promise for broad application in cancer immunotherapy.
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