Suppressing Cell Migration through Discoidal Bottlebrush Copolymer Nanocarriers.

Ping Zeng, Haoxiang Zeng, Jinsu Baek, Byungwoo Yoo, Byeong-Su Kim, Markus Müllner

Abstract read

In one paragraph

Article in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ping ZengKey Centre for Polymers and Colloids, School of Chemistry,The University of Sydney, Sydney 2006 NSW, Australia.

Haoxiang ZengKey Centre for Polymers and Colloids, School of Chemistry,The University of Sydney, Sydney 2006 NSW, Australia.ORCID https://orcid.org/0000-0001-8554-4717

Jinsu BaekDepartment of Chemistry, Yonsei University, Seoul 03722, Republic of Korea.ORCID https://orcid.org/0000-0002-6393-9176

Byungwoo YooDepartment of Chemistry, Yonsei University, Seoul 03722, Republic of Korea.ORCID https://orcid.org/0009-0009-8721-2682

Byeong-Su KimDepartment of Chemistry, Yonsei University, Seoul 03722, Republic of Korea.ORCID https://orcid.org/0000-0002-6419-3054

Markus MüllnerKey Centre for Polymers and Colloids, School of Chemistry,The University of Sydney, Sydney 2006 NSW, Australia.ORCID https://orcid.org/0000-0002-0298-554X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precise control over two-dimensional (2D) polymer nanostructures remains a fundamental challenge, as polymer self-assembly overwhelmingly favors spherical morphologies. Here, we introduce a topology-driven design strategy that overcomes this limitation, enabling the predictable and modular formation of amorphous polymer nanodiscs. Our strategy decouples nanodisc diameter from bottlebrush chemistry. By systematically varying the length of hydrophobic poly-(ethoxyethyl glycidyl ether) (PEE) side chains in the bottlebrush segment, we obtain precise control over nanodisc diameter while maintaining uniform thickness. This tunability allows investigation of size-dependent cellular interactions using MDA-MB-231 cancer cells. Importantly, we show that nanodiscs can serve as pH-responsive carriers that disassemble under acidic conditions and release ICAM-1 inhibitors (A-205804), resulting in effective suppression of cancer cell migration.

Indexed as

Cancer cell migrationDrug delivery systemsNanoparticlespH-responsiveSelf-assembly

Identifiers

PMID41889745

DOI10.1021/jacsau.6c00206

PMCPMC13014232

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.