Evidence map›Paper›PMID 41889761›Full record

ArticleJACS Au2026

Membrane Permeability Drives the Extreme Potency of Fentanyl.

Joseph Clayton, George J Farmer, Jacqueline Glenn, Shailesh N Mistry, J Robert Lane, Lei Shi, Lidiya Stavitskaya, Meritxell Canals, Jana Shen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Joseph ClaytonDivision of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, United States Food and Drug Administration, Silver Spring, Maryland 20993, United States.ORCID https://orcid.org/0000-0002-2652-5994
George J FarmerDivision of Biomolecular Science and Medicinal Chemistry, School of Pharmacy, and University of Nottingham Biodiscovery Institute, University Park, Nottingham NG7 2UH, U.K.
Jacqueline GlennCentre of Membrane Proteins and Receptors, Universities of Nottingham and Birmingham, Midlands NG7 2UH, U.K.
Shailesh N MistryDivision of Biomolecular Science and Medicinal Chemistry, School of Pharmacy, and University of Nottingham Biodiscovery Institute, University Park, Nottingham NG7 2UH, U.K.ORCID https://orcid.org/0000-0002-2252-1689
J Robert LaneCentre of Membrane Proteins and Receptors, Universities of Nottingham and Birmingham, Midlands NG7 2UH, U.K.ORCID https://orcid.org/0000-0002-7361-7875
Lei ShiComputational Chemistry and Molecular Biophysics Section, National Institutes on Drug Abuse - Intramural Research Program, Baltimore, Maryland 21224, United States.ORCID https://orcid.org/0000-0002-4137-096X
Lidiya StavitskayaDivision of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, United States Food and Drug Administration, Silver Spring, Maryland 20993, United States.ORCID https://orcid.org/0000-0002-6307-2314
Meritxell CanalsCentre of Membrane Proteins and Receptors, Universities of Nottingham and Birmingham, Midlands NG7 2UH, U.K.ORCID https://orcid.org/0000-0002-7942-5006
Jana ShenDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, United States.ORCID https://orcid.org/0000-0002-3234-0769

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fentanyl is a leading cause of drug overdose deaths in the United States, yet the mechanism driving its extreme

Indexed as

BRET reporter cellsmembrane permeationmolecular dynamicsmu-opioid receptoropioidspH partition hypothesis

Identifiers

PMID41889761
PMCPMC13014196

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.