Evidence map›Paper›PMID 41890274›Full record

ReviewBrain communications2026

Excitotoxicity in amyotrophic lateral sclerosis: a key pathogenic mechanism.

Silvia Silva-Hucha, Rosendo G Hernández, Diego Baena-López, María Estrella Fernández de Sevilla, Carmen Paradas, Sara Morcuende

Abstract readReview
In one paragraph

Review in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Silvia Silva-HuchaDepartamento de Fisiología, Facultad de Biología, Universidad de Sevilla, Sevilla 41012, Spain.ORCID https://orcid.org/0000-0002-8026-502X
Rosendo G HernándezDepartamento de Fisiología, Facultad de Biología, Universidad de Sevilla, Sevilla 41012, Spain.ORCID https://orcid.org/0000-0001-7098-8630
Diego Baena-LópezDepartamento de Fisiología, Facultad de Biología, Universidad de Sevilla, Sevilla 41012, Spain.ORCID https://orcid.org/0009-0009-6973-791X
María Estrella Fernández de SevillaDepartamento de Fisiología, Facultad de Biología, Universidad de Sevilla, Sevilla 41012, Spain.ORCID https://orcid.org/0000-0002-2693-1861
Carmen ParadasInstituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla 41013, Spain.ORCID https://orcid.org/0000-0002-6917-2236
Sara MorcuendeDepartamento de Fisiología, Facultad de Biología, Universidad de Sevilla, Sevilla 41012, Spain.ORCID https://orcid.org/0000-0003-1471-7005

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyotrophic lateral sclerosis is a complex neurodegenerative disease affecting motor neurons, characterized by the involvement of various factors, including oxidative stress, inflammatory processes, glutamate excitotoxicity, mitochondrial dysfunction, protein aggregation, axonal transport abnormalities, and apoptosis. The complexity of amyotrophic lateral sclerosis arises from its multifactorial aetiology involving diverse genetic, protein, metabolic, and cellular alterations. Mutations of different genes, such as

Indexed as

ALSglial cellsglutamatemotor neuronsneurodegenerative disorders

Identifiers

PMID41890274
PMCPMC13014077

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.