ReviewCureus2026
Mechanism-Based Management of Pain in Chronic Pancreatitis: An Integrated Narrative Review.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pain is the most frequent and debilitating manifestation of chronic pancreatitis (CP), substantially impairing quality of life and driving healthcare utilization. Despite advances in imaging and interventional therapies, effective pain control remains challenging because pain mechanisms are heterogeneous and often poorly correlated with the extent of structural pancreatic disease. Contemporary evidence indicates that CP-related pain arises from interacting nociceptive, neuropathic, and nociplastic pathways, shaped by pancreatic ductal obstruction, ongoing inflammation, neural remodeling, and central sensitization. This narrative review summarizes and contextualizes current evidence on the epidemiology, pathophysiology, and management of pain in CP, with a focus on a mechanism-based, multidisciplinary treatment approach. Conservative management, including lifestyle modification, nutritional optimization, pancreatic enzyme replacement for exocrine insufficiency, and stepwise analgesic and neuromodulatory pharmacotherapy, forms the cornerstone of care. Endoscopic and endoscopic ultrasound-guided interventions are beneficial in carefully selected patients with large-duct obstruction or identifiable nociceptive drivers but have limited efficacy in small-duct or centrally mediated pain. Surgical intervention offers the most durable pain relief in appropriately selected patients, particularly when undertaken early, before the establishment of central sensitization or opioid dependence; randomized trials support early surgery over prolonged endotherapy in painful obstructive CP. Recurrent pain following surgery is multifactorial and necessitates systematic reassessment to distinguish remediable structural disease from neuropathic or nociplastic pain. Overall, aligning therapeutic strategies with pancreatic ductal morphology and dominant pain mechanisms is critical to achieving sustained pain relief, minimizing opioid use, and improving long-term outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.