ArticleInternational journal of nanomedicine2026
A Dual-Stimuli Responsive Nanoplatform via Atomic Layer Deposition of Gold on CoFe
Article in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Targeted chemotherapy for colorectal cancer is often limited by nonspecific drug distribution and systemic toxicity. To improve local therapeutic efficacy and reduce side effects, we designed a thermally gated, dual-stimuli-responsive nanoplatform for controlled doxorubicin (DOX) delivery. Methods: CoFe Results: CFO/Au-2/PAA/DOX/TD exhibited a high DOX loading capacity (~26 wt%) and good colloidal stability. Minimal DOX leakage occurred at physiological temperature, confirming effective encapsulation by solid TD. Under NIR and/or AMF stimulation, the nanocomposite generated pronounced local heating, induced TD melting, and triggered rapid DOX release, with the combined NIR + AMF condition producing the fastest release profile. In vitro, the carrier without DOX showed minimal cytotoxicity toward SW620 cells, whereas CFO/Au-2/PAA/DOX/TD under dual stimulation produced significantly enhanced cytotoxicity toward SW620 cells compared with free DOX at the same drug concentration. Conclusion: This ALD-engineered CFO/Au-2/PAA/DOX/TD nanoplatform integrates magnetic and photothermal heating with thermally gated, dual-stimuli-responsive drug release, enabling precise spatiotemporal control of DOX delivery. The results suggest strong potential for combined and localized colorectal cancer therapy with reduced systemic toxicity.
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